Hyperhidrosis

(excessive sweating)

from £550

Dr Arun Karwal is the founder and lead practitioner at Karwal Aesthetics.

What Is Hyperhidrosis?

Hyperhidrosis is a condition characterised by sweating that exceeds what the body requires for thermoregulation. It is not a symptom of anxiety, poor hygiene, or any underlying systemic disease in most cases, though secondary hyperhidrosis, caused by an identifiable medical condition, does exist and should always be ruled out during your consultation.

Primary hyperhidrosis, by far the more common presentation, is caused by overactivity of the eccrine sweat glands, driven by the sympathetic nervous system. The eccrine glands are activated by acetylcholine, a neurotransmitter that signals the gland to produce sweat. In people with hyperhidrosis, this signalling is excessive and largely unrelated to temperature or physical exertion. The condition tends to run in families, often begins in adolescence or early adulthood, and is focal, meaning it typically affects specific areas rather than the entire body. The most commonly affected sites are the axillae (underarms), palms, and soles of the feet.

How Does Botox Treat Excessive Sweating?

Botulinum toxin works by temporarily blocking the release of acetylcholine at the neuromuscular junction. In aesthetic treatments, this mechanism relaxes muscle activity. In hyperhidrosis treatment, the same mechanism is applied to the eccrine sweat glands: when acetylcholine cannot bind to the gland's receptors, the gland does not receive the signal to produce sweat.

The effect is localised to the injection site. Botox for hyperhidrosis does not reduce sweating elsewhere on the body, and it does not interfere with the body's ability to regulate temperature overall. The eccrine glands in the treated area simply stop responding to the nerve signal, and sweating in that zone reduces dramatically.

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