At Karwal Aesthetics, we offer Plinest polynucleotides for various areas of the face and body:

• Face: Mid-face and lower face

• Eyes: Under-eye area, crow's feet, upper eyelids

• Neck and décolletage: For addressing crepey skin and horizontal lines

• Hands: To improve skin quality and reduce visible signs of ageing

The number of treatments required varies depending on individual concerns and goals:

• Initial course: Typically 2-4 sessions spaced 2-4 weeks apart

• Maintenance: Follow-up treatments every 6 months to maintain results

• Severe concerns: May require more intensive treatment protocols

Results from Plinest polynucleotide treatments develop gradually:

• Immediate: Some hydration and subtle glow may be visible straight away

• 2-4 weeks: Noticeable improvements in skin texture and tone

• 4-8 weeks: More significant improvements as collagen production increases

• 3-6 months: Optimal results become apparent

Results typically last 6-12 months, depending on individual factors such as age, lifestyle, and skin condition.

Polynucleotides are suitable for most adults looking to improve their skin quality. Ideal candidates include those who:

• Have early to moderate signs of ageing

• Want natural-looking rejuvenation without fillers

• Have sun-damaged or dehydrated skin

• Are looking for preventative anti-ageing treatments

• Have realistic expectations about results

We offer polynucleotide treatments at our clinic in London Mayfair. Our practice is conveniently located in the heart of Mayfair, one of London's most prestigious areas, making it easily accessible for clients across the capital.

Clinic Location

Address: 15 Dover Street, London, W1S 4LP

Our Mayfair clinic provides a luxurious and discreet environment where you can receive your Plinest treatments from Dr Arun, an experienced aesthetic practitioner. The clinic is equipped with modern facilities and adheres to the highest standards of safety and hygiene.

How to Find Us

• By Underground: Green Park station (Jubilee, Piccadilly, and Victoria lines) is just a short walk away

• By Bus: Multiple bus routes serve the Mayfair area

• By Car: Limited street parking available; several car parks nearby

To book your polynucleotides consultation or treatment, click here to schedule an appointment.

1. Improved Skin Texture: The treatment helps to smooth out fine lines and wrinkles, giving the skin a more refined texture.

2. Enhanced Elasticity: By boosting collagen production, Plinest Eyes improves skin elasticity, making it more resilient and firm.

3. Increased Hydration: The polynucleotides help to maintain moisture levels in the skin, preventing dryness and dullness.

4. Natural-Looking Results: The regenerative properties of polynucleotides provide a subtle and natural enhancement, avoiding the overly artificial look that some treatments can produce.

5. Minimal Downtime: Plinest Eyes is a minimally invasive procedure with little to no downtime, allowing individuals to resume their daily activities shortly after treatment.

1. Aftercare Notes for Sunekos, Profhilo & Plinest:

   • Needle entry points, redness, bruising, swelling and asymmetry around injection sites immediately after treatment is normal due to the very nature of the treatment.

   • There may also be some tenderness present as the bruising and inflammation sets in. These symptoms will resolve over the next 2-7 days, depending on your individual response to the treatment.

   For 24 hours avoid:

   • Touching your face

   • Applying makeup

   • Skincare with active ingredients

   • No alcohol

   • No exercise

   • No hot showers or sauna/steam rooms

Both Plinest and Sunekos are bio-revitalisation treatments, but they differ in their composition and mechanisms of action. Sunekos contains a patented formula of hyaluronic acid combined with a specific blend of amino acids, whilst Plinest uses polynucleotides derived from salmon DNA.

Key differences include:

• Active ingredients: Sunekos relies on hyaluronic acid and amino acids to stimulate the extracellular matrix, whereas Plinest uses polynucleotides for cellular regeneration and tissue repair.

• Mechanism: Sunekos works by providing the building blocks for collagen and elastin synthesis, whilst Plinest actively stimulates fibroblast activity and has additional anti-inflammatory and antioxidant properties.

• Treatment areas: Both can be used on similar areas, though Plinest Eye is specifically formulated for the periorbital region, whilst Sunekos has different formulations (Sunekos 200 and Sunekos 1200) for varying levels of skin laxity.

• Results: Both provide natural-looking improvements. However, Sunekos is the preferred product at Karwal Aesthetics, delivering more dramatic results and better improvement in hyperpigmentation, fine lines, and skin texture—especially crepey skin.

Both Plinest and Profhilo are bio-remodelling treatments that stimulate natural skin rejuvenation, but they differ in their composition and approach:

• Active ingredients: Profhilo contains highly concentrated hyaluronic acid (HA), whilst Plinest uses polynucleotides derived from salmon DNA.

• Mechanism of action: Profhilo works through bio-remodelling with HA to stimulate collagen and elastin production in four different types of collagen. Plinest works by directly stimulating fibroblast activity and has additional anti-inflammatory and antioxidant properties.

• Injection technique: Profhilo typically uses the BAP (Bio Aesthetic Points) technique with 5 injection points per side of the face, whilst Plinest requires multiple injection points distributed across the treatment area.

• Spread: Profhilo's unique formulation allows it to spread more easily under the skin after injection, whilst Plinest remains more localised to the injection sites.

• Hydration vs. regeneration: Profhilo primarily focuses on intense hydration and bio-remodelling, whilst Plinest emphasises cellular regeneration, tissue repair, and anti-inflammatory effects.

• Treatment areas: Both can be used on similar areas, though Profhilo is particularly noted for its lifting and hydrating effects on the face and neck, whilst Plinest offers targeted formulations like Plinest Eye for specific concerns.

• Results: Both provide natural-looking improvements. However, Profhilo is the preferred product at Karwal Aesthetics between the two. Profhilo delivers a natural glow, plumpness, and hydration to the skin.

Plinest polynucleotide treatments are generally well-tolerated, but some temporary side effects may occur:

• Mild swelling at injection sites

• Slight bruising (more common in sensitive areas)

• Redness or tenderness

• Small bumps at injection points

These effects typically resolve within 24-48 hours. Serious side effects are rare when performed by qualified practitioners.